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Tübingen - Atlanta

German - US-American Collaboration in Computational Neuroscience

"How dynamic is neuronal coding? State dependent stimulus sensitivity in thalamo-cortical networks in the vibrissal system of the rat"

The project examines the working hypothesis that neural coding in the cerebral cortex varies as a function of behavioral context. Simultaneous measurements of coding and behavior are planned, as well as their quantitative modeling and analysis. The relation between coding and behavioral context is represented in a quantitative and objective manner. The investigations will be performed on the example of the vibrissal system of the rat, which is one of the best-studied model sensorimotor systems. It is assumed that the results can be transferred to other cortex-based systems (sensation, movement, cognition) in animals and humans, because the underlying thalamo-cortical structure is very similar in these species.

In two blocks, cortical coding is investigated, depending on the individual’s state of alertness and the specific sensory task that the animal is executing. The experimental methods include behavioral training and multi-electrode electrophysiology. For the analysis, statistical models are applied and refined, in order to quantify the neuronal response to the associated sample of stimuli.

 


The following scientists take part in this collaboration:

  • Cornelius Schwarz, Systems Neurophysiology, Werner Reichardt Center for Integrative Neuroscience, Eberhard Karls University Tübingen
  • Garrett B. Stanley, Department of Biomedical Engineering, Georgia Tech & Emory University, Atlanta, USA

 

German Coordinator:

Prof. Dr. Cornelius Schwarz
Systems Neurophysiology
Werner Reichardt Center for Integrative Neuroscience       
Otfried-Müller-Str. 27
72076 Tübingen

Phone: +49 (0)7071 / 29 80462
Fax: +49 (0)7071 / 29 5724
e-mail: cornelius.schwarz@uni-tuebingen.de

 

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