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Frankfurt / Heidelberg - San Antonio

German - US-American Collaboration in Computational Neuroscience

"Effects of activity-dependent changes of chloride concentration on cerebellar function"

Over the last few years, it has become evident that inhibitory synapses are not static. Rather, their strength can be modulated by short-term and long-term changes in intracellular chloride concentration. The aim of this project is to better understand how temporally and spatially varying chloride-dependent activation of inhibitory synapses might affect the dendritic signal-integration in cerebellar Purkinje cells. In simulations, spatiotemporal changes in chloride concentration and synaptic inhibition will be computed to predict functional effects in cerebellar neurons. The predictions will be tested by cutting-edge experimental methods (chloride measurements, electrophysiology, 2-photon neurotransmitter photolysis).

 


The following scientists take part in this collaboration:

  • Peter Jedlicka, Institute for Clinical Neuroanatomy, NeuroScience Center, Johann Wolfgang Goethe University Frankfurt
  • Thomas Kuner, Institute of Anatomy and Cell Biology, Heidelberg University
  • Fidel Santamaria, Department of Biology, University of Texas at San Antonio, San Antonio, TX, USA

 

German Coordinator:

Dr. Peter Jedlicka
Institut für Anatomie I
Johann Wolfgang Goethe-Universität Frankfurt      
Theodor-Stern-Kai 7
60590 Frankfurt am Main

Phone: +49 (0)69 / 6301 6361
e-mail: jedlicka@em.uni-frankfurt.de

 

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