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Göttingen / Kiel - Nishinomiya / Tachikawa

German - Japanese Collaboration in Computational Neuroscience

Multidisciplinary reconstruction of the pan-network physiome generating spontaneous synchronized neural activity in the mammalian brain
(funded by DFG and JST)

Synchronized neuronal activity is fundamental in brain operation. Goal of the project is to reveal the pan-network physiome generating the synchronized activity of the respiratory network at different developmental stages using preparations that preserve spontaneous synchronous neuronal activity. In complex dynamic systems where numerous components interact mutually, a computational model to propose testable predictions for differentiating opposing hypotheses must be used. First, network organizations of each component of the respiratory network will be experimentally analyzed using fluorescence imaging in transgenic mice preparations and optogenetic tools for cell specific modulation. With these experimental results, the ground for a data-driven large-scale network model shall be set. Subsequently, the model will be converted into a neural mass model for describing the pan-network operation of the medullary respiratory centers. To complete the model, nontrivial predictions of functional roles of each component will be experimentally tested and iteratively fed back. The generation of such a pan-network model is essential for integrating still isolated physiological information. The model will unveil innovative aspects of the network interaction and help us to better understand pathological states of the network in life-threatening diseases like Rett syndrome, sudden infant death syndrome or congenital central hypoventilation syndrome.

 


The following scientists take part in this collaboration:

  • Prof. Swen Hülsmann, University of Göttingen
  • Dr. Andreas Galka, Kiel University
  • Prof. Yoshitaka Oku, Hyogo College of Medicine, Nishinomiya, Japan
  • Prof. Fumikazu Miwakeichi, Institute of Statistical Mathematics, Tachikawa, Japan

 

German Coordinator:

Prof. Swen Hülsmann
Georg-August-Universität Göttingen
Zentrum Physiologie und Pathophysiologie
Abteilung Neurophysiologie
und Zelluläre Biophysik
Humboldtallee   23  
37073 Göttingen

Tel.: +49 (0) 551 399592
Fax: +49 (0) 551 399676
e-mail: shuelsm2@gwdg.de

 

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