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Action-Potential Encoding

Bernstein Collaboration for Computational Neuroscience (BCOL)

The goal of the cooperation is to establish a comprehensive account of the impact of changing action potential (AP) encoding in regulating the degree of experience-dependent plasticity of neocortical circuits. The hypothesis will tested that alterations of AP-dynamics may modify plasticity in the visual cortex or influence the timing of the critical period and thus represent a powerful but presently virtually uncharacterized mechanism of cortical network development. The project will tackle these questions by combining a broad spectrum of experimental and theoretical approaches: in vivo optical imaging of cortical plasticity/behavioural assessment of visual capabilities (Jena group), in vitro electrophysiological analyses of AP dynamics and encoding (Bochum group), construction of phenomenological and biophysical models of dynamical AP encoding and its impact for synaptic plasticity (Göttingen group). The cooperation will thus integrate recently devised theoretical neuroscience methods into experimental projects and evaluate their potential for diagnostics and treatment of central nervous system disorders.

Subproject 1: Visual function and cortical plasticity in mice with genetically modified action potential dynamics

Subproject 2: Developmental change of dynamics of action potential initiation and encoding in visual cortical neurons of wild type and genetically modified mice

Subproject 3: Modelling the development of action potential encoding and its impact on the gating of developmental plasticity in the visual cortex